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HIPPOCAMPAL MORPOHLOGY AND CHILDHOOD TRAUMA
Figure 3.2 Left and right hippocampal volumes in different diagnosis groups
Abbreviations:
PTSD-only = patients with only posttraumatic stress disorder; PTSD-DID= patients with PTSD and dissociative identity disorder; HC= healthy controls; ** P-value<=0.001; * P-value ≤ 0.05; ^ 0.05 < P-value ≤ 0.1; n.s.: not significant
Hippocampal volume and severity of childhood traumatization
Bilateral global hippocampal volumes were significantly, or at a trend level, negatively correlated with severity of childhood emotional neglect, physical neglect, emotional abuse, sexual abuse and total traumatization (Table 3.3 and Figure 3.3). Subfield volumes of the left CA1, CA2-3, CA4-DG and (pre) subiculum, also showed correlations with severity of childhood traumatizing events. The strongest correlations were observed between left presubiculum volume and total childhood trauma (r=-0.64, p<0.001).
Hippocampal volume and dissociative symptoms
Significant negative correlations were found between severity of dissociative symptoms and the volumes of the left subiculum and presubiculum (Table 3.3). That is, the higher the severity of the psychoform and somatoform dissociative symptoms, the smaller the volume of the left subiculum and presubiculum.
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