Page 65 - Slipped Capital Femoral Epiphysis Pathogenetic and Clinical aspects

chronic diseases and SCFE. The role of anatomical factors related to SCFE is not the subject of this review.
Methods
Literature search
We performed systematic searches in the databases Pub-Med, EMBASE.com and
The Cochrane Library (via Wiley) from inception to 11th September 2012. Search
terms included controlled terms from MeSH in PubMed and EMtree in EMBASE.
com, as well as free-text terms. We used free-text terms only in The Cochrane
Library. Search terms expressing ‘epiphysiolysis’ were used, in combination with 4 search terms comprising ‘endocrine diseases’ or ‘biopsy’. The search was then
combined with terms for ‘extracellular matrix proteins, hormones’ and filtered for ‘children’ (Table 1). The references of the identified articles were searched for relevant publications.
Selection phase
Two reviewers (M.M.W. and E.P.J.) independently screened all potentially relevant titles and abstracts for eligibility. If necessary, the full-text article was checked for the eligibility criteria. Differences in judgment were resolved through a consensus procedure. Studies were included if they met the following criteria: studies discussing the histology of biopsies in SCFE physis, evaluation of hormonal factors influencing the human physis, SCFE and the ECM in the human physis. Exclusion criteria were articles not related to the human physis, animal-related research on the physis and drugs-related studies. The full text of articles was obtained for further review.
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