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Conclusions
SCFE is most likely the result of a multifactorial event during adolescence when height and weight increase dramatically and the delicate balance between the various hormonal equilibria can be disturbed. Up to now, there are no screening or diagnostic tests available to predict patients at risk.
Keywords Slipped capital femoral epiphysis; Systematic review; Endocrine, metabolic and chronic diseases
Abbreviations 4 AR Androgen receptor
CRF Chronic renal failure
ECM Extracellular matrix
ER Estrogen receptor
GC Glucocorticoids
GH Growth hormone
IGF-1 Insulin-like growth factor 1
IGF-1R Insulin-like growth factor 1 receptor IGFBP3 Insulin-like growth factor binding protein 3 IHH Indian hedgehog
IHH–PTHrH Indian hedgehog–parathyroid hormone-related hormone LH Luteinising hormone
MMP Matrix metalloproteinases
MMP13 Matrix metalloproteinase 13
MMP9 Matrix metalloproteinase 9
PTH Parathyroid hormone
rhGH Recombinant human growth hormone ROD Renal osteodystrophy
SCFE Slipped capital femoral epiphysis
T3 Triiodothyronine
T4 Thyroxine
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