Page 141 - The diagnostic work-up of women with postmenopausal bleeding

The accuracy of endometrial sampling
7
139
Table 3. Feasibility and diagnostic accuracy of endometrial sampling
Study and reference standard
Failed samples n (%)
Insufficient samples n (%)
(pre)cancer in failed/ insufficient samples n (%)
+ test (sens)
- test (spec)
+ test (sens)
- test (spec)
+test (sens)
- test (spec)
Blind D&C
Goldberg, ‘82 Accurette
5/40 (13)
7/35 (20)
2/12 (17) 2/11 (18) 0
0 1/23 (4) nr
3/3 (1.0) 3/3 (1.0) 3/3 (1.0) 9/9 (1.0) 2/2 (1.0) nr
25/25 (1.0) 26/26 (1.0) 8/8 (1.0) 36/36 (1.0) 5/5 (1.0) nr
8/9 (0.89) 9/9 (1.0) nr 10/10 (1.0) 2/2 (1.0) 5/7 (0.71)
19/19 (1.0) 20/20 (1.0) nr 35/35 (1.0) 5/5 (1.0)
nr nr nr nr 00 00
Vabra Batool,‘94
5/40 (13) 15/70 (21) 2/90 (2) 16/30 (53) 21/133 (16)
6/35 (17) 42/55 (76) 6/88 (16) 7/14 (50) 31/112 (28)
Ben-Baruch,‘94 Bunyavejchevin ‘01 Epstein ‘01
nr (0.99)
nr 10/31 (0.29)
nr
nr (0.99)
Hysteroscopy
vdBosch,‘95 vdBosch ‘96 Giusa-Chifieri,’96 Gupta,‘96
2/106 (2) 2/140 (1) 8/80 (10) 22/76 (29) 9/50 (18) 2/78 (3) 15/136 (11)
nr
0
5/5 (1.0)
80/80 (1.0) nr (0.99) 49/49 (1.0) 51/51 (1.0) 13/13 (1.0) 70/70 (1.0) 53/53 (1.0)
nr
nr (0.64) 17/18 (0.94) nr
nr 8/11 (0.73) 3/5 (0.56)
nr
20/39 (0.51) nr (0.45) nr 9/13 (0.69) 2/6 (0.33) 9/43 (0.21) nr
43/43 (1.0) nr (0.99) nr 40/41(0.98) 9/9 (1.0) 33/33 (1.0) nr
0
1/14 (7)
0
1/15 (7)
1 (?)
3/80 (4)
nr=not reported; sens = sensitivity; spec = specificity; endometrial disease = polyp/hyperplasia/cancer; *for total number of studies
De Silva ‘97 Mortakis ‘97 Spicer ‘06
nr 6/72 (8) nr 6/41 (15) nr 65/136 (48)
6/6 (1.0) 16/17 (0.94) 3/3 (1.0) 1/2 (0.5) 5/6 (0.83) 2/3 (0.67)
nr 48/48 (1.0) nr
nr 65/65 (1.0) 50/50 (1.0)
Endometrial cancer
Cancer or atypical hyperplasia
Endometrial disease