Page 138 - Biomarkers for risk stratification and guidance in heart failure
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Prognostic impact of change in NT-proBNP versus change in eGFR.
  Figure 2. Kaplan-Meier curve for the combined endpoint HF readmission or mortality (a) and mortality (b) by 20 % change in eGFR.
Change in eGFR was defined as 1) an increase in eGFR more than 20% (eGFR ↑ > 20%), 2) a change in eGFR less than 20% (eGFR =) and a decrease in eGFR more than 20% (eGFR ↓ > 20%).
In multivariate analysis a decrease or increase in eGFR more than 20% was not associated with risk for events compared with patients with a change in eGFR between 20% (HR for the combined endpoint 1.34, 95% CI 0.80–2.24, P=0.262 and HR 0.77, 95% CI 0.43–1.37, P=0.379 respectively).
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