Page 125 - Biomarkers for risk stratification and guidance in heart failure
P. 125

                                Chapter 5
Supplemental table 1. Correlation between NT-proBNP parameters.
  Admission Inpatient change Discharge Outpatient change One month
* p < 0.01, ** P<0.001
Admission Inpatient Discharge Outpatient change change
- 0.06 0.79** -0.19* 0.06 - 0.62** -0.13 0.79** 0.62** - -0.15* -.19* -0.01 -0.15* - 0.56** 0.56** 0.76** 0.45**
One month
0.56** 0.56** 0.76** 0.45** -
 Supplemental table 2. Multivariate analysis including group allocation (clinically-guided versus NT- proBNP-guided)
 Adjusted multivariate analysis*
 HR 95% CI
Wald p
3.8 0.052
5.3 0.021
5.4 0.020
0.7 0.415
6.3 0.012 20.1 <0.001 6.5 0.011 0.93 0.336
 Mortality
Inpatient decrease NT-proBNP 1.69 below vs above the median
Early outpatient increase versus 1.85 decrease in NT-proBNP
NT-proBNP at 1 month above versus 2.15 below the median
Group alllocation: clinically-guided 1.20 versus NT-proBNP-guided
HF readmission / mortality
Inpatient decrease NT-proBNP 1.71 below vs above the median
Early outpatient increase versus 2.69 decrease in NT-proBNP
NT-proBNP at 1 month above versus 1.86 below the median
Group allocation: clinically-guided 1.20 versus NT-proBNP-guided
* Adjusted for clinical parameters.
1.00-2.87 1.10-3.12 1.13-4.11 0.77-1.88
1.13 - 2.58 1.74 – 4.14 1.16 – 2.99 0.83-1.72
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