Page 100 - Biomarkers for risk stratification and guidance in heart failure
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                                Which heart failure patients profit from natriuretic peptide-guided therapy?
SUPPLEMENTARY TABLES
Suppl Table 1 Hazard ratio (HR) of HF admission comparing (NT-pro)BNP-guided therapy with symptom-
guided therapy with presence and absence of co-morbidities.
HFpEF
HR 95%-CI p HR
HFrEF
95%-CI p
0.62-1.10 0.18 0.61-1.00 0.05 0.66-1.05 0.12 0.56-1.10 0.15 0.63-0.97 0.03 0.63-1.49 0.90 0.67-1.09 0.22 0.57-1.03 0.08
     Hypertension No
Yes 0.96 0.59-1.57 0.88 0.78
Renal failure No
Yes 1.31 0.70-2.46 0.40 0.78
CVI No
Yes 0.67 0.26-1.68 0.39 0.97
Diabetes No
Yes 0.63 0.28-1.42 0.27 0.77
COPD No
Yes 1.30 0.49-3.47 0.60 0.77
1.19 0.53-2.65 0.68 0.82
0.86 0.49-1.50 0.60 0.83
1.10 0.69-1.76 0.69 0.78
1.23 0.75-2.03 0.41 0.86
0.99 0.62-1.57 0.97 0.80
0.65-0.99 0.50-1.17 0.22 0.65-1.01 0.06 0.66-1.98 0.63 0.59-1.09 0.16 0.66-1.09 0.19 0.65-1.05 0.12 0.56-1.30 0.45
PVD No
Yes 2.10 0.67-6.53 0.20 1.15
0.30-1.79 0.50 0.85
Abbreviations: CVI = cerebro-vascular insult (also includes transient ischemic attack), Dm = diabetes mellitus, COPD = chronic obstructive pulmonary disease, PVD = peripheral vascular disease.
Suppl Table 2 Number of patients and number of events in the different subgroups, related to the presence and absence of co-morbidities.
CVI/Dm/ COPD No
Yes 0.78 0.43-1.41 0.41 0.85
CVI/Dm/ COPD/PVD No
Yes 0.74
0.92 0.57-1.48 0.73 0.81
1.37 0.74-2.54 0.32 0.80 1.15 0.71-1.88 0.57 0.83
0.04 4
       Hyper-tension Renal failure CVI
Diabetes COPD
PVD
CVI/Dm/ COPD CVI/Dm/ COPD/PVD
# of patients whole group
No 79 Yes 216 No 179 Yes 117 No 238 Yes 58 No 207 Yes 89 No 252 Yes 44 No 225 Yes 60 No 144 Yes 152 No 122 Yes 163
HFpEF
# of deaths
18 50 36 33 43 15 60 29 55 14 44 21 22 47 16 49
# of HF admissions
24 65 50 39 70 19 63 26 72 17 68 16 42 47 34 50
# of patients whole group
742
982 1184 395 1327
HFrEF
# of deaths
129 181 204 108 249
# of HF admissions
185 254 282 135 333
253 63 84 1182 195 262 549 117 180 1442 252 356 289 60 86
1229 174 782 798 658 745
219 304 56 54 120 161 192 256 97 132 178 226
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