Page 32 - Fertility in Women with Rheumatoid Arthritis Vruchtbaarheid van vrouwen met reumatoïde artritis

Chapter 2
median TTP was 0.50 year (IQR 0.19–1.28). Pregnancy resulted in a live born baby in 178 women (87%), 26 women (13%) miscarried and there was one intra-uterine fetal death. Thirty- ve pregnant women had had fertility treatment. These women did not differ signi cantly from the other subjects. No data on fertility assessments were available. Since only a few patients used cyclo-oxigenase-2 (COX-2) inhibitors, traditional NSAIDs and COX-2 inhibitors were regarded as one group for analyses.
In 61 women (25%) who were not assessed preconceptionally, only the rst trimester DAS28 was available. In women who had been visited both preconceptionally and during pregnancy (n=109), a paired t test showed no signi cant difference between the preconception DAS28 (3.57±1.1) and the rst trimester DAS28 (3.56±1.2; p=0.93). The rst trimester DAS28 in these 109 women did not differ from the rst trimester DAS28 in women who had not been assessed preconceptionally (3.53±1.1; p=0.86)., The rst trimester DAS28 was used for further analyses if the preconception DAS28 was missing.
Figure 1 – Flow chart showing the number of patients in the Pregnancy-induced Amelioration of Rheumatoid Arthritis (PARA) study who were available for the current analysis. ACPA, anti-citrullinated peptide antibodies; ACR, American College of Rheumatology; DAS28, 28-joint Disease Activity Score; RF, rheumatoid factor.
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